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    BiS, Biointerface Science in Regenerative Medicine at the Department of Biomedical Engineering, Eindhoven University of Technology

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BiS is part of the Biomedical Engineering Department at TU/e. Research at BiS is dedicated to understanding and applying basic cell biological principles at the biointerfaces especially for regenerative medicine. The research program is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology to streamline the wealth of biological knowledge to real clinical applications.



Research at BiS

Cell biology, computational approaches, and material development are the three key fields of science that we focus our research on at BiS. To find out more, have a look here:



Jan de Boer
Burcu Gumuscu Sefunc
Sultan Gülçe Iz
Jorge Alfredo Uquillas
Nusrat Malik 2
Mehmet Tas
Ayşegül Dede
Urandelger (Urnaa) Tuvshindorj
Kerbaï Saïd Eroumé
Phani Sudarsanam
Katinka Klap
Miguel Faase

Suggested reading

Interested in the history of the TopoChip technology?

Read this short assay by Jan de Boer entitled: ”  On mixing people and ideas - a brief history of the TopoChip”



Recruitment of case owners, and a responsible teacher with a background in data science for the USE learning line Digital Twins in Healthcare

jan de boer My name is Jan de Boer, professor of BioInterface Science at BME and I am developing the USE learning line “Digital Twin in Healthcare together with my colleagues from the TU/e departments of Biomedical Engineering (BME), Mechanical Engineering (ME), Industrial Engineering and Innovation Science (IE & IS), and the faculty of Medicine at the UMC Utrecht.

This USE LL aims to teach engineers about the role of technology in the healthcare system, the impact of technology on patients, and the role  of the engineer in this ecosystem. Digital Twins are the scaffolds on which we build a curriculum.

We use a modular approach. Each module is based on a clinical case which is organized by a case owner, who is a TU/e teacher who brings in her/his favorite digital twin topic. We already have several cases, for example, atrial fibrillation, metabolic profiling in diabetes, scoliosis surgery and medical imaging using catheters. However, we are actively recruiting case owners. Each case owner brings along a clinical liaison, a company liaison and organizes the tutors needed to run the USE case. Challenge-based learning (CBL) is our main teaching strategy.

The USE LL comprises of three modules, each of 5 ECTS: Conceiving, Designing and Operating/Implementing. Each module has a responsible teacher. The conceiving phase is coordinated by Burcu Gumuscu (BME) who will design the learning methods to bring the pieces of the puzzle to the students, the stake holders, the technology, and the medical problem. The Operating/Implementation phase is coordinated by Wybo Houkes (IE & IS) who will show the students how a digital twin can be used off campus: with patients, in hospitals, and as part of a company portfolio.

For the second phase of this USE LL (Designing phase) we are looking for a responsible teacher with a background in the data science of Digital Twins, with experience in modeling, machine learning, AI, and databases. A creative thinker who can link her/his expertise to coordinate the data science of the clinical cases in collaboration with the case owners and the responsible teachers of the Conceiving and Operating/Implementing phase.

USE LL Digital Twin in Healthcare received a grant from the Educational Innovation fund, and we have recruited a full-time project manager for the duration of two years to support the USE LL in the development of the educational material. Innovation Space is also involved in the development of the curriculum. In the first year, this learning line will receive 100 students, but we expect to grow in the future. Revenues of teaching are proportionally distributed among the departments.

If you are interested in either the role as case owner or responsible teacher, please contact me at This email address is being protected from spambots. You need JavaScript enabled to view it.



  • BiS-Biointerface Science in Regenerative Medicine
  • TU/e Department of Biomedical Engineering
Eindhoven University of Technology
PO Box 513
5600 MB, Eindhoven
This email address is being protected from spambots. You need JavaScript enabled to view it.
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