New publication in Tissue Engineering Part B: Reviews

The first article of Phani Sudarsanam's PhD dissertation has now been accepted for publication in the journal Tissue Engineering Part B: Reviews.

Biomaterials are widely used to manufacture medical devices, but implantation is associated with a foreign body response (FBR), which may lead to failure of the implants. Surface properties are related to FBR severity. In this review, we zoom in on the crosstalk between the two key players, macrophages, and fibroblasts, and propose the use of Adverse Outcome Pathways to decipher the causal link between material properties and the severity of the FBR. This approach will help increase a mechanistic understanding of the FBR, and thus aid in the design of immuno-modulatory implant surfaces.

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