• News

    News

  • News

    News

  • News

    News

  • Home
  • News
  • New article on dynamic cell adaption to surface geometry

New article on dynamic cell adaption to surface geometry

22 June 2022

In this research article, we investigated how cells organize their adhesive machinery over time upon exposure to microfabricated surfaces of different topographies and adhesive island geometries.

Furthermore, we examined the reciprocal interaction between stress fiber and focal adhesion formation by pharmacological perturbations. Our results confirm the current literature that spatial organization of adhesive sites determines the ability to form focal adhesions and stress fibers. Therefore, cells on roughened surfaces have smaller focal adhesion and fewer stress fibers. This further highlights the importance of integrinmediated adhesion in the adaptive properties of cells and provide clear links to the development of bioactive materials.

2022 0622 frontier article

Figure 1. Tendon imprint-induced cell shape changes

Click here to read more.