New article on dynamic cell adaption to surface geometry
In this research article, we investigated how cells organize their adhesive machinery over time upon exposure to microfabricated surfaces of different topographies and adhesive island geometries.
Furthermore, we examined the reciprocal interaction between stress fiber and focal adhesion formation by pharmacological perturbations. Our results confirm the current literature that spatial organization of adhesive sites determines the ability to form focal adhesions and stress fibers. Therefore, cells on roughened surfaces have smaller focal adhesion and fewer stress fibers. This further highlights the importance of integrinmediated adhesion in the adaptive properties of cells and provide clear links to the development of bioactive materials.
Figure 1. Tendon imprint-induced cell shape changes
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