New review on the Loop Phenotype in Acta Biomaterialia
This review article discusses the dynamic reciprocity between cells and their surrounding extracellular matrix (ECM), also known as the Loop of Phenotype, for tendon tissue homeostatis.
The article describes cell shape and ECM organization in normal and diseased tissue, how ECM composition influences tenocyte shape, and how that leads to the activation of signal transduction pathways and ECM deposition, as well as the use of technologies to control cell shape to elucidate the link between cell shape and its phenotypical markers and focus on the causal role of cell shape in the loop of phenotype.
Read the article here.
