Bioinspired microfabrication for smart materials
Burcu is a tenure-track assistant professor in the Department of Biomedical Engineering at TU/e. She strives for the development, fabrication, and application of smart biomaterials to realize high-precision processing in high-throughput microfluidic settings. She specifically focuses on the design and development of lab-on-a-chip devices containing hydrogels for diversified life sciences applications. She is also interested in combining data-mining and machine learning techniques with hypothesis-driven experimental research for future research. Previously, she worked as a senior researcher in Mesoscale Chemical Systems Research Group at the University of Twente, where she performed independent research on nano-fabricated arrays for biomolecule analysis. In 2017 and 2018, she was a postdoctoral fellow in the Bioengineering Department at the University of California, Berkeley, where she developed microfluidic biosensors for single-cell analysis. She received her Ph.D. degree in Bioengineering from the BIOS Lab-on-a-chip group at the University of Twente. Her Ph.D. thesis primarily aimed at the design and development of microfluidic devices for next-generation sequencing, organ‐on-chip, and water desalination on the microscale. She is the recipient of the Pieter Langerhuizen grant given in 2019 by The Royal Holland Society of Sciences (KHMW). Burcu serves as a web writer at the Royal Society of Chemistry in collaboration with the development editor of Lab on a Chip Journal, and a review editor in Frontiers in Digital Health Journal.https://orcid.org/0000-0003-4843-4724
Developing in vitro tests to assess medical implant safety
Els first became interested in the intersection of cell biology and materials science while studying for her undergraduate degree in Natural Sciences at the University of Cambridge (UK). She continued this interest during her master’s degree in Biomedicine at Karolinska Institutet (Sweden), completing two research internships in the field of biomaterials in the groups of Prof. My Hedhammar and Prof. Molly Stevens. In 2020 she started her PhD at the RIVM National Institute for Health and the Environment, in collaboration with the Biointerface Science group of Prof. Jan de Boer at TU/e. In her PhD project, she will be developing in vitro tests to assess medical implant safety, focusing on the foreign body response. These tests will assess the effects of not only chemical but also mechanical stimuli, which are not measured by the current standard toxicity tests. To evaluate the predictive value of the tests, she will also examine clinical reference samples of implants removed from patients with complaints.
I Fon obtained her Bachelor and Master in Science degree from the National University of Singapore, where she has also worked as a research assistant and laboratory executive. Her research focussed on the role of Endoplasmic Reticulum protein 29 and Cytokeratin-19 in breast cancer progression. She has extensive experience in flow cytometry. As lab administrator, she manages the day-to-day operational, organizational, and administrative functions of BioInterface Science group.
Jan is interested in the molecular complexity of cells and how molecular circuits are involved in cell and tissue function. With a background in mouse and Drosophila genetics, he entered the field of biomedical engineering in 2002 and has since focused on understanding and implementing molecular biology in the field of tissue engineering and regenerative medicine. His research is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology to streamline the wealth of biological knowledge to real clinical applications. His research is defined by strong interdisciplinary collaborations through his big network. He is the former chair of the Netherlands Society for Biomaterials and Tissue Engineering and founder and former chair of the MosaCell platform for patient-derived stem cell research. He brought transcriptomics and computational sciences into his research established a data repository cBIT and his current team comprises both experimental and computational scientists. Jan is a full professor at Biomedical Engineering Department, Eindhoven University of Technology (TU/e), chair of BiS, Biointerface Science in Regenerative Medicine since 2018. He was a founding member of the Merln Institute for Technology-Inspired Regenerative Medicine, Maastricht University and chair of cBITE, Cell Biology Inspired Tissue Engineering Lab between 2014-2018 and worked as an associate professor at the MIRA Institute for Biomedical Technology, University of Twente between 2004-2014.
Understanding the mechanics, biology and proprioception of anterior cruciate ligament reconstruction
Jorge has a deep understanding of basic medical sciences, biochemistry, cell & molecular biology, regenerative medicine, and engineering. He is passionate about translating novel medical discoveries in orthopedics, trauma, and neurology to the clinic. For example, over the past 5 years, his team at the EPICS research group at Purdue University has been developing a fully automated CPR device to be used in emergency scenarios in low-income countries. Additionally, he led the regenerative medicine laboratory at Axxis Hospital in Ecuador and held professorship positions in cell/molecular biology, medical biochemistry, biomaterials, and tissue engineering at several universities in Ecuador. He is also very interested in entrepreneurship and medical device innovation. In the past few years, he has spearheaded efforts in Ecuador to organize medical hackathons alongside MIT Hacking Medicine, which are events that put together medical personnel, engineers, software developers, and business people to work on diverse medical problems. He holds a Ph.D. in Orthopaedics Bioengineering from Purdue University and trained as a postdoctoral fellow at Harvard Medical School, the Brigham and Women's Hospital, and the Koch Institute at MIT. His research interests include a) vascularization strategies in tissue-engineered hydrogels, b) regeneration, control of knee arthrosis using growth factors, cells, and drug delivery strategies, and c) mechanotransduction and mechanoinduction of stem cells via natural surfaces.
Juul graduated from Radboud University Nijmegen with a bachelor’s and master’s degree in Biomedical Sciences. At Radboud University, she focused her academic coursework on molecular and (stem) cell biology, animal disease modelling, and nanomedicine. Driven by a particular interest in the field of regenerative medicine, cellular biology, and biomaterial science, her research projects involved establishing the effect of elastin receptor complex signalling on cell regenerative capacities, as well as studying the intracellular uptake of copper-containing mesoporous bioactive glass nanoparticles. In October 2021, she joined the BioInterface Science group of Prof. Jan de Boer and started her PhD, in which she aims to identify adhesive surface patterns for Golgi nanosurgery and topographical surfaces that promote Golgi biogenesis.
I'm Lanhui Li. I’m an experimental chemist working in the microfluidic field. I received my PhD this year in May from the University of Twente, BIOS Lab-on-a-chip. During my PhD, my research projects involve surface modification of microfluidic devices with stimuli-responsive polymer and developing and optimization of droplet-based and capillarity-based microfluidic devices, aiming at on-chip manipulation technique of droplets and liquid flow thus is essential for diagnostics and bioengineering. Starting from May 17th, I became a new postdoc of the Biointerface Science Lab. My project is designing and producing micro-patterned glaucoma shunts.
Nikita has gained his interest at the intersection of cellular biology and biomaterials shortly before defending the bachelor’s thesis in NUST “MISiS” as a nanotechnologist. The background was followed by a Nanobiophysics masters degree at TU Dresden. There he researched the temporal effect upon the earliest moments of C. elegans oocyte’s development. In the summer 2021, he has happily joined prof. de Boer’s BiS lab at the TU/e. With the goal to investigate the interaction between material induced mechanotransduction and canonical signaling pathway, particularly in the area of fibrosis.
Topographic approach to address the problem of foreign body response in glaucoma drainage devices
Phani comes from southern part of India where he did his bachelors in biotechnology in 2011. He got interested in the inter disciplinary scope of the field while working at a company where he was a part of the project to test active drug efficacy from different phytochemical plant extracts for anti cancerous activity. In 2013, he started his masters in university of Tuebingen (Germany) in biomedical technologies where he took implantology as one of his specialization with focus on biomaterials which really fascinated him. As a part of his thesis, he did his project titled “In-vitro evaluation of small molecules for anti microbial activity in gram negative bacteria” which focuses on the characterisation of active hits from high throughput screening. As a part of his Ph.d, he will be focusing his research on performing high throughput screening of topographies to address the fibrotic response in glaucoma shunt devices used in treatment of glaucoma to reduce the intra ocular pressure. The objective of the project is to develop surface topographies with anti-fibrotic properties that can avoid implant failure.
A short poster presentation of Phani's current research can be found here.
Tim obtained his Bachelor's and Master's degree in Biomedical Engineering at the University of Technology, Eindhoven. For his master's degree, he joined the research group of computational biology and worked on the network-based analysis of human hepatic cells, to identify clinical relevant genotype-phenotype differences from liver biopsies in subgroups of nonalcoholic fatty liver disease patients. in 2016, he joined the group of Toxicogenomics at Maastricht University for his Ph.D. During his Ph.D., he focused on the interaction between the epigenome and transcriptome in cancer cell lines and population studies. Here, he applied omics integration techniques to extract relevant features to build genomic interaction networks. As a data manager, he will manage and further design the data infrastructure and explore the implementation of a biomaterial atlas.
Binary coded, digital biointerfaces – a next generation biomaterials approach with spatially complex subcellular patterns of discrete surface and near-surface properties
In 2009 Urnaa started her bachelor studies in Chemical Engineering at Gazi University (Turkey). During her studies she became interested in material science and started working in the surface chemistry lab. After finishing her bachelor’s degree in 2013, she started her master’s degree in Material Science and Nanotechnology at Bilkent University. During her master she worked on organically modified silica nanostructure based functional surfaces. In 2016 she started a PhD project in Maastricht where she will be developing binary coded digital bio-interfaces with subcellular discrete patterned surfaces using micro- and nanofabrication tools to investigate cell-material interactions.