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Data Manager - Materials-Driven Regeneration Gravitation Program

JOB DESCRIPTION: 

The Research Center for Materials-Driven Regeneration (MDR) is a partnership between Eindhoven University of Technology, Maastricht University and Utrecht University, University Medical Center Utrecht and the Hubrecht Institute. This consortium was brought together to advance tissue and organ regeneration approaches with the use of instructive biomaterials. The MDR Research Center was awarded a 18.8 M€ grant in May 2017 by the ministry of education, culture and science of The Netherlands in the framework of the Gravitation program.

The project runs within the Strategic Programme RIVM (SPR) in which we conduct innovative research. The aim of SPR is to innovate and to generate knowledge that helps to prepare RIVM to respond to future issues in health and sustainability.

About the Data Manager position: 

  • Consider the various ways data sets are created, collected, analysed, visualized and stored in the different disciplines
  • Define a data architecture that brings out the best of the collective data sets (or investigate how we can) and is attractive for MDR scientists to use and improve, and that provides handles to faithfully and robustly answer some of the scientific questions of the consortium
  • Showcase the added value and power (if any) of data science in this multidisciplinary arena to the scientific community
  • Consider/discuss/investigate/question the ethical aspects, the legal aspects, and the intellectual ownership of a complex data set owned by many scientists, across disciplines and universities
  • Deal with the logistics (location, costs, access routes, etc) of the MDR data sets
  • Develop principles for storing raw data
  • Develop guidelines for reproducible data analysis
  • Enable and promote the archiving, storage and managing of research data according to academic FAIR (Findability, Accessibility, Interoperability, and Reusability) principles
  • Couple data architecture and enabled FAIR principles to the broader university infrastructure applicable for the full BME department

APPLY:

To learn more about this position and send an application, please click here. If you have any further questions, please contact Prof. dr. Jan de Boer at This email address is being protected from spambots. You need JavaScript enabled to view it.

PhD Position in Medical Implant Safety Research

JOB DESCRIPTION: 

Medical implants are available for a wide variety of health problems. They are greatly diverse in size and composition, ranging from very small vascular stents to large hip replacements. They are made from different materials with accompanying material properties. Examples are hip implants, pacemakers and pelvic floor meshes. The vast majority of patients benefits from the use of medical implants. However, a group of patients can develop adverse health complaints, such as pain and migration of the implant.

Current standards for the biological evaluation of medical implants mostly rely on toxicity tests originally developed for chemical substances. Adverse health effects caused by medical implants may be initiated by chemical or mechanical stimuli, or a combination. The standard toxicity tests are not developed to measure mechanical stimuli. Within this PhD-project you will develop innovative tests using both chemical and mechanical stimuli to assess implant safety. These tests rely on an in vitro cell culture model that will be used for biomaterial exposure via a direct cell-biomaterial interaction that can assess the effects of both the chemical and mechanical stimuli. Application of the test will focus on the foreign body response in the context of complications due to fibrotic encapsulation.

In this project you will: (i) investigate the applicability of various cell types (cell lines, primary cells, iPSCs) to assess implant safety, (ii) develop a cell culture model for direct cell-material interaction, (iii) develop assays to measure key-events involved in the foreign body response, and (iv) evaluate the innovative tests using clinically derived reference samples of medical implants removed from patients with complaints.

Prof. dr. Jan de Boer from the department of Biomedical Engineering of the Technical University Eindhoven will be your promotor. Your home office and primary laboratories will be at the RIVM, However, the TU/e facilities are available as well when specialized equipment is needed in order to execute certain experiment. Additionally you will be exptected to closely collaborate with the de Boer’s research group, including regular attendance at their work discussions and journal clubs and scientific discussions about the PhD-project. Furthermore, we will work with multiple (inter)national partners, including Maxima Medical Centre Veldhoven.

The project runs within the Strategic Programme RIVM (SPR) in which we conduct innovative research. The aim of SPR is to innovate and to generate knowledge that helps to prepare RIVM to respond to future issues in health and sustainability.

JOB REQUIREMENT: 

We are looking for a motivated researcher with the following requirements:

  • A Master’s degree in Biomedical Engineering, Toxicology or a related field
  • Interest in biomaterials, cell-material interaction and immunology
  • Experienced in cell culturing of cell lines and or primary cells. Knowledge on induced pluripotent stem cells is not required but preferred
  • Prior experience with molecular biology assays
  • Eager to work application-driven
  • Sound understanding of basic bio-statistics
  • Keen to learn about complex/multimodal data interpretation
  • Communicate and coordinate effectively and efficiently with members of our multidisciplinary project team
  • Able to multitask and prioritize
  • Abie to work independently and as part of a team to deliver high-quality work
  • Excellent written and verbal communication skills in English at a level appropriate to the research.

APPLY:

If you are interested, please click here to submit an application. If you have any further questions, please contact Prof. dr. Jan de Boer at This email address is being protected from spambots. You need JavaScript enabled to view it.

 

M.Sc. Project Available

Colorimetric detection of Lithium in whole blood using microfluidic circuits

INTRODUCTION

Medication adherence refers to whether individuals take their medications as prescribed by their physician. Medication non-adherence problem affects not only the individuals but also the health care system.(1) Non-adherent individuals often fail to start taking their pills, fail to take the correct dose, or stop taking pills before completing the treatment. According to the WHO, only half (and down to 4%) of patients with chronic illnesses (such as obstructive pulmonary disease, coronary syndrome, psychological disorders, etc.) take their medications regularly.(2)

A commonly used technique for direct assessment of medication adherence is the automatic medication event monitoring systems, which are electronic pill holders sending reminders to individuals to take pills and logging the pill-taking events.(3) Other techniques include observed therapy or measurement of biological markers added to the drug formulation from the blood. While the individuals tend to ‘snooze’ the notifications of electronic pill holders or manage to place fake pills instead of the prescribed ones, measurement of biological markers requires to convince the individuals to go to a hospital or a controlled analysis laboratory, where high operation costs and the need for dedicated tools arise as a problem.

Using microfluidics, we can monitor colorimetric changes created by the presence of medicinal metabolites in functionalized hydrogels.(4) A quantitative analysis of such changes enables the detection of target markers along with supporting cues.

ASSIGNMENT

The goal of this project is to develop a microfluidic sensing system to capture target molecules are produced as a result of metabolized medicines in the body. The project consists of several steps including, (1) investigation of the drug metabolites and sensing molecules giving colorimetric reactions upon exposure, (2) integration of the sensing molecules into the microfluidic system, (3) improvement of the system for optimal results. The model study from Koh et al. (5) could be considered as a starting point for this project.

BACKGROUND

We are looking for enthusiastic M.Sc. students with a background in biomedical engineering or mechanical engineering. If you are interested, please contact Burcu Gumuscu SefuncThis email address is being protected from spambots. You need JavaScript enabled to view it. for further details. 

REFERENCES

  1. Jimmy, B., & Jose, J. (2011). Patient medication adherence: measures in daily practice. Oman medical journal26(3), 155.
  2. World Health Organization (2003) Adherence to long term therapies: Evidence for action. Available at https://www.who.int/chp/knowledge/publications/adherence_report/en/
  3. Abderrahman, B. (2017). Health literacy, medication adherence and thriving healthcare systems: connecting the dots. Clinical Pharmacology, 9(11), 322-24.
  4. https://www.unodc.org/documents/scientific/Screening_Colour_Test_ATS.pdf
  5. Koh, A., Kang, D., Xue, Y., Lee, S., Pielak, R. M., Kim, J., ... & Manco, M. C. (2016). A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat. Science translational medicine, 8(366), 366ra165-366ra165.

Contact

  • BiS-Biointerface Science in Regenerative Medicine
  • TU/e Department of Biomedical Engineering
Eindhoven University of Technology
PO Box 513
5600 MB, Eindhoven
This email address is being protected from spambots. You need JavaScript enabled to view it.
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