PhD in Signal Transduction at the Cell-Biomaterial lnterface
Eindhoven University of Technology
TU/e is a University of Technology with a focus on Health, Energy, and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines.
The Department of Biomedical Engineering (BME) offers a research-driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and nontenured employees.
Starting from an existing transcriptomic database, i.e. the Compendium for Biomaterial Transcriptomics a.k.a CBiT, the candidate will identify cell signaling events that are unique to cell-biomaterial interaction and will help us understand biomaterial-related issues such as fibrosis and infection, but also to provide guiding principles to engineer bio-active materials. The PhD candidate is expected to do scientific research in the field described above, write a doctoral thesis, and publish research results in scientific journals. An educational and professional development program is offered to all PhD candidates. You will also be involved in teaching courses offered by the group, as well as contribute to the supervision of bachelor and master students.
We are accepting applications from enthusiastic and highly talented candidates who are interested in a dynamic, stimulating, and ambitious environment to perform their research.
We are looking for candidates that meet the following requirements:
- A background in Cell Biology (or similar) and interested in computational tools for hypothesis generation or in Bioinformatics (or similar) and interested to learn and master wet lab cell biology approaches to validate generated hypothesis.
- Effective communication of ideas, foster collaborations, and have a capability for independent thinking.
- Work independently within a dynamic team and be proficient in written and spoken English.
The research will be conducted within the Biolnterface Science (BIS) group in the Department of Biomedical Engineering under the supervision of prof.dr. Jan de Boer (www.jandeboerlab.com). Research at BiS is dedicated to understanding and applying basic cell biological principles at the biointerfaces, especially for regenerative medicine. The research program is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling, and experimental biology to streamline the wealth of biological knowledge to real clinical applications.